The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia,Alzheimer's & Dementia

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The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2021-08-17 , DOI: 10.1002/alz.12428
Andrea Du Preez ₁ , Sophie Lefèvre-Arbogast ₂ , Vikki Houghton ₁ , Chiara de Lucia ₁ , Dorrain Y Low ₃ , Catherine Helmer ₂ , Catherine Féart ₂ , Cécile Delcourt ₂ , Cécile Proust-Lima ₂ , Mercè Pallàs ₃ , Silvie R Ruigrok ₄ , Barbara Altendorfer ₅ , Raúl González-Domínguez _{6,

7} , Alex Sánchez-Pla _{6,

7} , Mireia Urpi-Sardà _{6,

7} , Cristina Andres-Lacueva _{6,

7} , Ludwig Aigner ₅ , Paul J Lucassen ₄ , Aniko Korosi ₄ , Claudine Manach ₈ , Cécilia Samieri ₂ , Sandrine Thuret _{1,

9}

Affiliation

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France.
Pharmacology Section, Department of Pharmacology, Toxicology and Medicinal Chemistry, Pharmacy and Food Sciences, and Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Brain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, The Netherlands.
Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Austria.
Nutrition, Food Science and Gastronomy Department, Pharmacy and Food Science, University of Barcelona, Spain.
CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Barcelona, Spain.
Université Clermont Auvergne, INRA, UMR1019, Human Nutrition Unit, France.
Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Diet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise-triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors might act in concert with hippocampal neurogenesis (HN) to shape CD and dementia.

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