Objective

The present study investigated differences between opioids to experimental tonic pain in healthy men.

Methods

Twenty-one males participated in this cross-over-trial. Interventions twice daily were oxycodone (10 mg), tapentadol (50 mg) and placebo for 14 days. Tonic pain was induced on day 1, 4 and 14 by immersing the hand in 2 °C water for 120 s. Electroencephalography was recorded during test pain at baseline and after 14 days. Spectral analysis and source localization were investigated in predefined frequency bands.

Results

A decreased perception of pain on day 4 persisted throughout the 14 days compared to baseline (p < 0.006). Oxycodone decreased the electroencephalography spectral power in the delta and theta bands and increased power in the alpha1, alpha2 and beta1 bands (p < 0.03). Tapentadol increased spectral power in the alpha1 band (p < 0.001). Source localization revealed that oxycodone decreased activity of the temporal and limbic region in the delta band, and frontal lobe in the alpha2 and beta1 bands, whereas tapentadol decreased alpha1 band activity in the temporal lobe compared to placebo.

Conclusion

Oxycodone and tapentadol reduced pain perception and changed the central processing of tonic pain.

Significance

Different mechanisms of action were involved, where oxycodone affected cortical structures more than tapentadol.

中文翻译：

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他喷他多和羟考酮对强直性疼痛中枢处理的影响

客观的

本研究调查了阿片类药物与健康男性实验性强直性疼痛之间的差异。

方法

21 名男性参加了这次交叉试验。每天两次的干预措施是羟考酮（10 毫克）、他喷他多（50 毫克）和安慰剂，为期 14 天。通过将手浸入 2°C 水中 120 秒，在第 1、4 和 14 天诱发强直性疼痛。在基线和 14 天后的测试疼痛期间记录脑电图。在预定义的频带中研究了频谱分析和源定位。

结果

与基线相比，第 4 天的疼痛感在 14 天内持续减少（p < 0.006）。羟考酮降低了 delta 和 theta 波段的脑电图谱功率，增加了 alpha1、alpha2 和 beta1 波段的功率（p < 0.03）。他喷他多增加了 alpha1 波段的光谱功率（p < 0.001）。源定位显示，与安慰剂相比，羟考酮降低了 delta 带中颞叶和边缘区以及 alpha2 和 beta1 带中的额叶的活性，而他喷他多降低了颞叶中的 alpha1 带活性。

结论

羟考酮和他喷他多降低了痛觉并改变了强直性疼痛的中枢处理。

意义

涉及不同的作用机制，其中羟考酮对皮质结构的影响大于他喷他多。