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Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines
RSC Chemical Biology Pub Date : 2021-08-12 , DOI: 10.1039/d1cb00132a
Weifeng Lin 1 , Zhen Yang 1 , Amanpreet Kaur 1 , Annika Block 1 , Miroslav Vujasinovic 2 , J-Matthias Löhr 2, 3 , Daniel Globisch 1
Affiliation  

The investigation of microbiome-derived metabolites is important to understand metabolic interactions with their human host. New methodologies for mass spectrometric discovery of undetected metabolites with unknown bioactivity are required. Herein, we introduce squaric acid as a new chemoselective moiety for amine metabolite analysis in human fecal samples.

中文翻译:

方酸作为一种新的化学选择性部分,用于基于质谱的胺代谢组学分析

微生物组衍生代谢物的研究对于了解与人类宿主的代谢相互作用非常重要。需要新的质谱发现具有未知生物活性的未检测代谢物的方法。在此,我们引入方酸作为一种新的化学选择性部分,用于人类粪便样品中胺代谢物的分析。
更新日期:2021-08-17
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