While much has been written about the syndrome of diabetic cardiomyopathy, clinicians and research scientists are now beginning to realize that an entirely unique syndrome exists, albeit with several commonalities to the diabetic syndrome, that being obesity cardiomyopathy. This syndrome develops independent of such comorbidities as hypertension, myocardial infarction and coronary artery disease; and it is characterized by specific alterations in adipose tissue function, inflammation and metabolism. Recent insights into the etiology of the syndrome and its consequences have focused on the roles played by altered intracellular calcium homeostasis, reactive oxygen species, and mitochondrial dysfunction. A timely and comprehensive review by Ren, Wu, Wang, Sowers and Zhang (1) identifies unique mechanisms underlying this syndrome, its relationship to heart failure and the recently identified incidence of COVID-19-related cardiovascular mortality. Importantly, the review concludes by advancing recommendations for novel approaches to the clinical management of this dangerous form of cardiomyopathy.

中文翻译：

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肥胖和心肌病

虽然关于糖尿病性心肌病综合征的文章很多，但临床医生和研究科学家现在开始意识到存在一种完全独特的综合征，尽管与糖尿病综合征有几个共同点，那就是肥胖型心肌病。这种综合征的发展与高血压、心肌梗塞和冠状动脉疾病等合并症无关；它的特点是脂肪组织功能、炎症和代谢的特定改变。最近对该综合征病因学及其后果的见解集中在细胞内钙稳态改变、活性氧和线粒体功能障碍所起的作用上。Ren、Wu、Wang、Sowers 和 Zhang (1) 及时、全面地回顾了这种综合征背后的独特机制，它与心力衰竭和最近确定的 COVID-19 相关心血管死亡率的关系。重要的是，该综述最后提出了对这种危险形式的心肌病的临床管理新方法的建议。