Furoxan as precursor: An operationally simple assembly of pharmacologically oriented fully substituted furoxans and isoxazoles was achieved. The presented protocol is based on a one-pot ring cleavage/nucleophilic addition/oxidation cascade of readily available monosubstituted furoxans. Synthesized disubstituted furoxans revealed an ability to release NO which indicate their strong potential as drug candidates for various biomedical applications.

中文翻译：

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环畸变多样性导向方法完全取代呋喃和异恶唑

Furoxan 作为前体：实现了药理学取向的完全取代的呋喃和异恶唑的操作简单组装。所提出的协议基于一锅环裂解/亲核加成/氧化级联的现成的单取代呋喃。合成的二取代呋喃烷显示出释放 NO 的能力，这表明它们作为各种生物医学应用的候选药物具有强大的潜力。