Stem cell-like memory T cells (Tscm), are a newly defined memory T cell subset with characteristics of long life span, consistent self-renewing, rapid differentiation into effector T cells, and apoptosis resistance. These features indicate that Tscm have great therapeutic or preventive purposes, including being applied in chimeric Ag receptor-engineered T cells, TCR gene-modified T cells, and vaccines. However, the little knowledge about Tscm development restrains their applications. Strength and duration of TCR signaling, cytokines and metabolism in the T cells during activation all influence the Tscm development via regulating transcriptional factors and cell signaling pathways. Here, we summarize the molecular and cellular pathways involving Tscm differentiation, and its clinical application for cancer immunotherapy and prevention.

中文翻译：

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干细胞样记忆T细胞的产生和应用

干细胞样记忆T细胞（Tscm）是一种新定义的记忆T细胞亚群，具有寿命长、持续自我更新、快速分化为效应T细胞和抗凋亡等特点。这些特征表明 Tscm 具有很好的治疗或预防目的，包括应用于嵌合 Ag 受体工程 T 细胞、TCR 基因修饰的 T 细胞和疫苗。然而，对Tscm发展的了解限制了它们的应用。TCR 信号的强度和持续时间、激活过程中 T 细胞中的细胞因子和代谢都通过调节转录因子和细胞信号通路影响 Tscm 的发展。在这里，我们总结了涉及 Tscm 分化的分子和细胞途径，及其在癌症免疫治疗和预防中的临床应用。