Dietary supplementation with NAD+ precursors or ketone esters has been shown to improve mitochondrial function in preclinical models of heart failure with either reduced or preserved ejection fraction. Both supplementation approaches hold promise but are in the early stages of development as clinical therapies for heart failure.

中文翻译：

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通过膳食补充剂促进心力衰竭患者的线粒体代谢

在射血分数降低或保持的心力衰竭临床前模型中，膳食补充 NAD+ 前体或酮酯已被证明可以改善线粒体功能。这两种补充方法都有希望，但作为心力衰竭的临床疗法仍处于开发的早期阶段。