Abstract

In the present study, via using the mixed ligand synthesis approach, two new transition metal coordination polymers (CPs) [Co(3-bptpa)(1,3-BDC)]·DMA·2H₂O (1) and [Cu(3-bptpa)(5-MIP)] (2) (3-bptpa = N,N′-bis(pyridine-3-yl)thiophene-2,5-dicarboxamide, 1,3-H₂BDC = 1,3-benzenedicarboxylic acid, 5-H₂MIP = 5-methylisophthalic acid, DMA = N,N-dimethylacetamide), were solvothermally/hydrothermally synthesized. Their prevention activity on hypotension after spinal anesthesia was evaluated and the related mechanism was explored at the same time. First of all, the blood pressure of the animal after the spinal anesthesia and CPs exposure was measured. Next, the relative expression levels of the α receptor on the vascular endothelial cells was determined with real time RT-PCR (reverse transcription-polymerase chain reaction).

摘要

在本研究中，通过使用混合配体合成方法，两种新的过渡金属配位聚合物（CPs）[Co(3-bptpa)(1,3-BDC)]·DMA·2H ₂ O ( 1 ) 和[Cu( 3-bptpa)(5-MIP)] ( 2 ) (3-bptpa = N,N'-双(吡啶-3-基)噻吩-2,5-二甲酰胺，1,3-H ₂ BDC = 1,3 -苯二甲酸，5-H ₂MIP = 5-甲基间苯二甲酸，DMA = N,N-二甲基乙酰胺），是溶剂热/水热合成的。评价了它们对腰麻后低血压的预防作用，同时探讨了相关机制。首先，测量脊髓麻醉和CPs暴露后动物的血压。接下来，用实时RT-PCR（逆转录-聚合酶链反应）测定血管内皮细胞上α受体的相对表达水平。