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Dynamic perfusion analysis in acute ischemic stroke: A comparative study of two different softwares
Clinical Hemorheology and Microcirculation ( IF 2.1 ) Pub Date : 2021-08-15 , DOI: 10.3233/ch-219106
Cornelius Krusche 1 , Carolina Rio Bartulos 1 , Mazen Abu-Mugheisib 2 , Michael Haimerl 3 , Philipp Wiggermann 1
Affiliation  

BACKGROUND:In clinical practice, decisions often must be made rapidly; therefore, automated software is useful for diagnostic support. Perfusion computed tomography and follow-up evaluation of perfusion data are valuable tools for selecting the optimal recanalization therapy in patients with acuteischemic stroke. OBJECTIVE:This study aimed to compare commercially available software used to evaluate stroke patients prior to thrombectomy. METHODS:The performance of Olea Sphere (OlS) software vs. CT Neuro Perfusion from Syngo (Sy), as well as the electronic Alberta Stroke Program Early Computed Tomography Score (e-ASPECTS) software vs. an experienced radiologist, were compared using descriptive statistics including significance analysis, Spearman’s correlation, and the Bland-Altman agreement analysis. For this purpose, 43 data sets of patients with stroke symptoms related to the middle cerebral artery territory were retrospectively post-processed with both tools and analyzed. RESULTS:The automatic e-ASPECTS showed high agreement with an expert rater assessment of the ASPECTS. Using OlS and Sy, we compared the parameters for the ischemic core (relative cerebral blood flow), Time to maximum (Tmax) for the penumbra, and the relative mismatch between these two values. Overall, both software tools achieved good agreement, and their respective values correlated well with each other. However, OlS predicted significantly smaller infarct core volumes compared with Sy. CONCLUSIONS:Although the absolute values have a certain degree of variation, both software programs have good agreement with each other.

中文翻译:

急性缺血性脑卒中的动态灌注分析:两种不同软件的比较研究

背景:在临床实践中,往往必须迅速做出决定;因此,自动化软件可用于诊断支持。灌注计算机断层扫描和灌注数据的随访评估是为急性缺血性卒中患者选择最佳再通治疗的宝贵工具。目的:本研究旨在比较用于评估血栓切除术前卒中患者的市售软件。方法:使用描述性比较了 Olea Sphere (OlS) 软件与 Syngo (Sy) 的 CT Neuro Perfusion,以及电子艾伯塔中风程序早期计算机断层扫描评分 (e-ASPECTS) 软件与经验丰富的放射科医生的性能统计包括显着性分析、Spearman 相关性和 Bland-Altman 一致性分析。以此目的,使用这两种工具对 43 组与大脑中动脉区域相关的中风症状患者的数据集进行回顾性后处理和分析。结果:自动 e-ASPECTS 与专家评估者对 ASPECTS 的评估高度一致。使用 OlS 和 Sy,我们比较了缺血核心参数(相对脑血流量)、半影的最大值时间 (Tmax) 以及这两个值之间的相对不匹配。总体而言,这两种软件工具都取得了良好的一致性,并且它们各自的值相互关联良好。然而,与 Sy 相比,OlS 预测的梗死核心体积明显更小。结论:虽然绝对值有一定程度的变化,但两个软件程序之间具有很好的一致性。
更新日期:2021-08-17
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