B-cell lymphoma is a group of hematological malignancies with high clinical and biological heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction between tumor cells and the tumor microenvironment (TME), which is composed of stromal cells and extracellular matrix. Although the roles of the TME have not been fully elucidated, accumulating evidence implies that TME is closely relevant to the origination, invasion and metastasis of B-cell lymphoma. Explorations of the TME provide distinctive insights for cancer therapy. Here, we epitomize the recent advances of TME in B-cell lymphoma and discuss its function in tumor progression and immune escape. In addition, the potential clinical value of targeting TME in B-cell lymphoma is highlighted, which is expected to pave the way for novel therapeutic strategies.

中文翻译：

---

靶向 B 细胞淋巴瘤的肿瘤微环境：挑战与机遇

B细胞淋巴瘤是一组具有高度临床和生物学异质性的血液系统恶性肿瘤。B 细胞淋巴瘤的发病机制涉及肿瘤细胞与由基质细胞和细胞外基质组成的肿瘤微环境 (TME) 之间的复杂相互作用。尽管 TME 的作用尚未完全阐明，但越来越多的证据表明 TME 与 B 细胞淋巴瘤的起源、侵袭和转移密切相关。TME 的探索为癌症治疗提供了独特的见解。在这里，我们概括了 TME 在 B 细胞淋巴瘤中的最新进展，并讨论了其在肿瘤进展和免疫逃逸中的作用。此外，突出了靶向 TME 在 B 细胞淋巴瘤中的潜在临床价值，有望为新的治疗策略铺平道路。