Pituitary metastasis is a rare situation in clinical practice and has been estimated to take up no more than 1% of tumors found in sellar region, in which the incidence of a secondary metastatic lesion to the sella by hepatocellular carcinoma (HCC) is extremely rare, only 15 cases of which has been reported yet. The aim of this study is to share the detailed procedures and clinical strategies of this rare case and review the whole 15 HCC-derived PM cases since 1857. We present an extremely rare case of an HCC metastasis to the pituitary gland with his condition and clinical course. We then discuss the dominant diagnosis and clinical therapy of HCC-derived PM and review the literature. This case demonstrated the difficulties encountered in the diagnosis of PM and the need for accurate judgment when confronting pituitary tumors with atypical features. In addition, the appropriate therapy needs to be well considered, because of the poor prognosis and severe symptoms.

Abbreviations: CTA: computed tomography angiography; ETTS: endoscopic transnasal transsphenoidal surgery; HCC: hepatocellular carcinoma; ICA: internal carotid artery; PET-CT: positron emission tomography-computed tomography; PM: pituitary metastasis

垂体转移在临床实践中是一种罕见的情况，据估计在鞍区发现的肿瘤中不超过 1%，其中肝细胞癌 (HCC) 继发性转移到蝶鞍的发生率极为罕见，其中仅报告了 15 例。本研究的目的是分享这一罕见病例的详细程序和临床策略，并回顾自 1857 年以来 15 例 HCC 衍生的 PM 病例。课程。然后我们讨论了 HCC 源性 PM 的主要诊断和临床治疗并回顾了文献。该病例说明了在面对具有非典型特征的垂体肿瘤时，PM诊断遇到的困难和需要准确判断的问题。此外，由于预后差且症状严重，需要充分考虑适当的治疗方法。

缩写： CTA：计算机断层扫描血管造影；ETTS：内窥镜经鼻蝶窦手术；HCC：肝细胞癌；ICA：颈内动脉；PET-CT：正电子发射断层扫描-计算机断层扫描；PM：垂体转移