The conventional orthotopic/xenograft models or genetically engineered murine models of colon cancer (CRC) are limited in their scope for a true understanding of tumor growth, progression and eventual metastasis in its natural microenvironment. In the currently used murine models of CRC metastasis, the metastasis occurs primarily in the liver, though lung metastasis accounts for a significant proportion of CRC metastasis. There is an urgent need for a murine model of CRC, which not only allows tumor progression in the colonic mucosa but also metastasis of the lung. The authors describe a minimally invasive murine model of colon cancer progression that may be ideal for a wide range of applications, including evaluating gene function, microenvironment, cancer metastasis and therapeutic translational research.

中文翻译：

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基于结肠镜检查的癌细胞黏膜内移植用于结肠癌和肺转移的小鼠建模。

传统的原位/异种移植模型或结肠癌 (CRC) 的基因工程小鼠模型的范围有限，无法真正了解肿瘤在其自然微环境中的生长、进展和最终转移。在目前使用的 CRC 转移鼠模型中，转移主要发生在肝脏中，尽管肺转移占 CRC 转移的很大一部分。迫切需要一种 CRC 的小鼠模型，它不仅允许结肠粘膜中的肿瘤进展，而且还允许肺转移。作者描述了一种结肠癌进展的微创小鼠模型，该模型可能是广泛应用的理想选择，包括评估基因功能、微环境、癌症转移和治疗性转化研究。