Intrathecal nusinersen administration can be challenging in certain adult spinal muscular atrophy (SMA) patients with difficult spinal anatomy who require imaging techniques (fluoroscopy or computed tomography scans) or invasive approaches (catheter placement, laminotomy) to identify the intrathecal space. We used ultrasound (US) assistance to access the lumbar intrathecal space in patients with SMA who experienced previous difficulties or failures with intrathecal dosing.

中文翻译：

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超声辅助腰椎鞘内注射 nusinersen 治疗成人脊髓性肌萎缩症：病例系列

对于需要影像技术（透视或计算机断层扫描）或侵入性方法（导管放置、椎板切开术）来识别鞘内空间的某些脊柱解剖困难的成人脊髓性肌萎缩症 (SMA) 患者，鞘内注射 nusinersen 可能具有挑战性。我们使用超声 (US) 辅助进入曾经历过鞘内给药困难或失败的 SMA 患者的腰椎鞘内空间。