Hepatitis E viruses (HEV) are an underestimated global cause of enterically transmitted viral hepatitis, which may persist in immunocompromised hosts, posing a risk for progressive liver fibrosis with limited treatment options. We previously established liver-humanized mice as a model for chronic HEV infections, which can be cleared by a 2-week pegylated (peg)-Interferon(IFN)α treatment course. However, severe side effects may hamper the use of IFNα in immunocompromised transplant recipient patients. IFNλ may be a valuable alternative, as its receptor is less ubiquitously expressed.

中文翻译：

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通过干扰素-λ在肝人源化小鼠中治疗诱导清除戊型肝炎病毒

戊型肝炎病毒 (HEV) 是肠道传播病毒性肝炎的一个被低估的全球原因，它可能在免疫功能低下的宿主中持续存在，在治疗选择有限的情况下构成进行性肝纤维化的风险。我们之前建立了肝脏人源化小鼠作为慢性 HEV 感染的模型，可以通过为期 2 周的聚乙二醇化 (peg)-干扰素 (IFN)α 治疗过程清除。然而，严重的副作用可能会阻碍 IFNα 在免疫功能低下的移植受者患者中的使用。IFNλ 可能是一种有价值的替代品，因为它的受体表达较少。