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Fluorescent Carbon Dot–Curcumin Nanocomposites for Remarkable Antibacterial Activity with Synergistic Photodynamic and Photothermal Abilities
ACS Applied Bio Materials ( IF 4.7 ) Pub Date : 2021-08-16 , DOI: 10.1021/acsabm.1c00377
Hongjun Yan 1 , Baoqu Zhang 2 , Ying Zhang 1 , Rixiang Su 1 , Peiyuan Li 1 , Wei Su 2
Affiliation  

Photosensitizer (PS)-mediated photodynamic therapy (PDT) has attracted more and more attention as an alternative to traditional antibiotic therapy. Nevertheless, the limitations of traditional photosensitizers seriously hinder their practical application, as a result, the methods to improve the antibacterial properties of traditional photosensitizers have become a hot topic in the field of photomedicine. Herein, a compound nano-PS system has been constructed with synergistic photodynamic and photothermal (PTT) antibacterial effects, triggered by a dual-wavelength illumination. Fluorescent carbon dots (CDs) were synthesized and employed as carriers for the delivery of curcumin (Cur) to obtain CDs/Cur. Upon combined near-infrared and 405 nm visible dual-wavelength irradiation, CDs/Cur could simultaneously generate ROS and a moderate temperature increase, triggering synergistic antibacterial effects against both Gram-positive and Gram-negative bacteria. The results of scanning electron microscopy and fluorescence confocal imaging showed that the combined effect of CDs/Cur with PDT and PTT caused more serious damage to the cell membrane. In addition, CDs/Cur exhibited low cytotoxicity and negligible hemolytic activity, showing great biocompatibility. Therefore, the construction of CDs/Cur by employing CDs as photosensitizer delivery carriers provides a strategy for the improvement of the antibacterial effect of the photosensitizer and the design of next-generation antibacterial agents in photomedicine.

中文翻译:

具有协同光动力和光热能力的荧光碳点-姜黄素纳米复合材料具有显着的抗菌活性

光敏剂 (PS) 介导的光动力疗法 (PDT) 作为传统抗生素疗法的替代疗法越来越受到关注。然而,传统光敏剂的局限性严重阻碍了其实际应用,因此,如何提高传统光敏剂的抗菌性能已成为光医学领域的热门话题。在此,我们构建了一种复合纳米 PS 系统,该系统具有协同光动力和光热 (PTT) 抗菌效应,由双波长照明触发。合成荧光碳点 (CDs) 并将其用作递送姜黄素 (Cur) 的载体以获得 CDs/Cur。在组合近红外和 405 nm 可见光双波长照射后,CDs/Cur 可以同时产生 ROS 和适度的温度升高,触发对革兰氏阳性和革兰氏阴性细菌的协同抗菌作用。扫描电镜和荧光共聚焦成像结果表明,CDs/Cur与PDT和PTT的联合作用对细胞膜的损伤更为严重。此外,CDs/Cur 表现出低细胞毒性和可忽略的溶血活性,显示出良好的生物相容性。因此,以CDs为光敏剂递送载体构建CDs/Cur,为提高光敏剂的抗菌效果和设计下一代光医学抗菌剂提供了策略。扫描电镜和荧光共聚焦成像结果表明,CDs/Cur与PDT和PTT的联合作用对细胞膜的损伤更为严重。此外,CDs/Cur 表现出低细胞毒性和可忽略的溶血活性,显示出良好的生物相容性。因此,以CDs为光敏剂递送载体构建CDs/Cur,为提高光敏剂的抗菌效果和设计下一代光医学抗菌剂提供了策略。扫描电镜和荧光共聚焦成像结果表明,CDs/Cur与PDT和PTT的联合作用对细胞膜的损伤更为严重。此外,CDs/Cur 表现出低细胞毒性和可忽略的溶血活性,显示出良好的生物相容性。因此,以CDs为光敏剂递送载体构建CDs/Cur,为提高光敏剂的抗菌效果和设计下一代光医学抗菌剂提供了策略。
更新日期:2021-09-20
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