Induced pluripotent stem cell (iPSC) technology, which enables the direct analysis of neuronal cells with the same genetic background as patients, has recently garnered significant attention in schizophrenia research. This technology is important because it enables a comprehensive interpretation using mice and human clinical research and cross-species verification. Here I review recent advances in modeling schizophrenia using iPSC technology, alongside the utility of disease mouse models.

中文翻译：

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用 iPS 细胞技术和疾病小鼠模型模拟精神分裂症

诱导多能干细胞 (iPSC) 技术能够直接分析与患者具有相同遗传背景的神经元细胞，最近在精神分裂症研究中引起了广泛关注。这项技术很重要，因为它可以使用小鼠和人类临床研究和跨物种验证进行全面解释。在这里，我回顾了使用 iPSC 技术对精神分裂症建模的最新进展，以及疾病小鼠模型的实用性。