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Sex bias in alcohol research: A 20-year comparative study
Frontiers in Neuroendocrinology ( IF 7.4 ) Pub Date : 2021-08-16 , DOI: 10.1016/j.yfrne.2021.100939
Mianhuan Li 1 , Yibo Qu 2 , Jiajun Zhong 3 , Zhaodi Che 3 , Hua Wang 4 , Junjie Xiao 5 , Fei Wang 6 , Jia Xiao 3
Affiliation  

We aimed to assess the sex-inclusive and sex-based analysis bias in alcohol research for the past 20 years. Data were abstracted from 2988 original research articles published from 2000 through 2019 in 51 representative journals across 9 biomedical disciplines. An analysis in 5-year intervals revealed that the percentage of studies using participants of both sexes was significantly higher between 2015 and 2019 than between 2000 and 2014. When stratified, clinical studies showed a higher percentage of both-sex studies compared to basic studies using animals. The reasons for the use of single-sex cohorts mainly included insufficient participant numbers and misconceptions surrounding the hormonal variability of females. Implementation of the NIH SABV policy promoted the ratio of NIH-funded papers with sex-based analyses. In conclusion, sex bias in alcohol-related biomedical studies has improved over the past 20 years, particularly after the implementation of the SABV policy. Although clinical studies increasingly included sex-based analysis, basic studies were biased towards the use of males.



中文翻译:

酒精研究中的性别偏见:一项 20 年的比较研究

我们旨在评估过去 20 年酒精研究中的性别包容性和基于性别的分析偏差。数据来自 2000 年至 2019 年在 9 个生物医学学科的 51 个代表性期刊上发表的 2988 篇原创研究文章。以 5 年为间隔的分析显示,2015 年至 2019 年期间使用男女参与者的研究百分比显着高于 2000 年至 2014 年之间。分层时,临床研究显示,与使用男女参与者的基础研究相比,临床研究的百分比更高动物。使用单性别队列的原因主要包括参与者人数不足和对女性荷尔蒙变异性的误解。NIH SABV 政策的实施提高了 NIH 资助的基于性别分析的论文的比例。综上所述,在过去 20 年中,与酒精相关的生物医学研究中的性别偏见有所改善,特别是在实施 SABV 政策之后。尽管临床研究越来越多地包括基于性别的分析,但基础研究偏向于使用男性。

更新日期:2021-08-21
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