Chemical orthogonality, defined as 100% selectivity in chemical reactions, has proven to be a powerful concept making significant impacts in the fields of synthetic organic chemistry, chemical biology, and materials science. The review by James F. Reuther and coworkers on page 1748 details the recent advancements towards the use of chemically orthogonal reactions in synthetic polymer chemistry, allowing the synthesis of complex, structurally diverse polymer microstructures and topologies. Utilization of orthogonal “click” chemistry post-polymerization yielded complex materials that are not possible using traditional polymerization techniques. The advent of stimuli-triggered orthogonal polymerization methods that differ in mechanism has provided streamlined, one-pot routes to unique block and bottle-brush copolymer structures simplifying procedures for synthesis and purification. (DOI: 10.1002/pol.20210345)

中文翻译：

---

封面图片

化学正交性，定义为化学反应中的 100% 选择性，已被证明是一个强大的概念，在合成有机化学、化学生物学和材料科学领域产生重大影响。James F. Reuther 及其同事在第 1748 页上的评论详细介绍了在合成聚合物化学中使用化学正交反应的最新进展，允许合成复杂的、结构多样的聚合物微结构和拓扑结构。利用正交“点击”化学后聚合产生了使用传统聚合技术无法实现的复杂材料。机制不同的刺激触发正交聚合方法的出现提供了流线型、独特的嵌段和瓶刷共聚物结构的一锅法，简化了合成和纯化的程序。（DOI：10.1002/pol.20210345）