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Physicochemical characterization of the gelatin/polycaprolactone nanofibers loaded with diclofenac potassium for topical use aiming potential anti-inflammatory action
International Journal of Polymeric Materials and Polymeric Biomaterials ( IF 3.2 ) Pub Date : 2021-08-15 , DOI: 10.1080/00914037.2021.1962875
Gabriella Onila do Nascimento Soares 1 , Flávia Alves Lima 2 , Gisele Assis Castro Goulart 2 , Rodrigo Lambert Oréfice 1
Affiliation  

Abstract

Common adversities as gastrointestinal discomfort are related to conventional administration of diclofenac potassium (DP), and thus the study of a new administration route based on gelatin/polycaprolactone electrospun nanofibers loaded with DP is an innovative way to create biomaterials for topical delivery of drugs aiming the patients’ life quality improvement. SEM-EDS evidenced success in the drug incorporation, while FTIR and DSC indicated possible gelatin and DP interaction. In vitro biodegradation and in vitro release studies showed the gelatin dissolution and dependence of the release profile with the DP wt. % and temperature, respectively. In vitro permeation presented a dermal targeting of DP.



中文翻译:

负载双氯芬酸钾的明胶/聚己内酯纳米纤维的物理化学表征,用于局部使用,旨在潜在的抗炎作用

摘要

胃肠道不适等常见不良反应与双氯芬酸钾 (DP) 的常规给药有关,因此研究一种基于载有 DP 的明胶/聚己内酯电纺纳米纤维的新给药途径是一种创新的方法来创造用于局部递送药物的生物材料,旨在患者生活质量的提高。SEM-EDS 证明药物掺入成功,而 FTIR 和 DSC 表明可能存在明胶和 DP 相互作用。体外生物降解和体外释放研究表明明胶溶解和释放曲线与 DP wt 的依赖性。% 和温度,分别。体外渗透呈现 DP 的皮肤靶向。

更新日期:2021-08-15
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