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Synthesis of D–π–A type benzothiazole–pyridinium salt composite and its application as photo-degradation agent for amyloid fibrils
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2021-08-14 , DOI: 10.1016/j.bmcl.2021.128324 Keita Hoshi 1 , Kazuma Kusumoto 1 , Airi Matsumoto 2 , Atsushi Tabata 2 , Hideaki Nagamune 2 , Eiji Hase 3 , Takeo Minamikawa 3 , Takeshi Yasui 3 , Yasushi Yoshida 4 , Keiji Minagawa 1 , Yasushi Imada 1 , Fumitoshi Yagishita 5
中文翻译：
D-π-A型苯并噻唑-吡啶鎓盐复合物的合成及其作为淀粉样原纤维光降解剂的应用
更新日期：2021-08-20
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2021-08-14 , DOI: 10.1016/j.bmcl.2021.128324 Keita Hoshi 1 , Kazuma Kusumoto 1 , Airi Matsumoto 2 , Atsushi Tabata 2 , Hideaki Nagamune 2 , Eiji Hase 3 , Takeo Minamikawa 3 , Takeshi Yasui 3 , Yasushi Yoshida 4 , Keiji Minagawa 1 , Yasushi Imada 1 , Fumitoshi Yagishita 5
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We have synthesized a cyan fluorescent benzothiazole–pyridinium salt composite based on D–π–A architecture. This salt was found to work as not only a two- and three-photon excitable fluorophore but also a degradation agent against amyloid fibrils under LED irradiation conditions.
中文翻译：
D-π-A型苯并噻唑-吡啶鎓盐复合物的合成及其作为淀粉样原纤维光降解剂的应用
我们合成了一种基于 D-π-A 结构的青色荧光苯并噻唑-吡啶鎓盐复合材料。发现这种盐不仅可用作两光子和三光子可激发荧光团，而且在 LED 照射条件下还可用作抗淀粉样蛋白原纤维的降解剂。
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