It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its repair. Thus, chromatin arises as a guardian of the stability of the genome, which is altered in cancer cells. In this review, we focus into the mechanisms by which chromatin influences the occurrence and repair of the most cytotoxic DNA lesions, double-strand breaks, in particular at actively transcribed chromatin or related to DNA replication.

中文翻译：

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不同染色质环境中 DNA 损伤发生率和修复的异质性

众所周知，基因组的某些区域比其他区域更容易受到损伤和诱变。最近的进展已经确定了染色质在损伤发生率和修复中的关键作用。因此，染色质作为基因组稳定性的守护者出现，在癌细胞中发生了改变。在这篇综述中，我们关注染色质影响最具细胞毒性 DNA 损伤（双链断裂）发生和修复的机制，特别是在活跃转录的染色质或与 DNA 复制相关的情况。