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Effect of time and temperature-dependent changes of IOL material properties on IOL: Lens capsule interactions
Experimental Eye Research ( IF 3.4 ) Pub Date : 2021-08-14 , DOI: 10.1016/j.exer.2021.108726
Arjun Jaitli , Joyita Roy , Amjad Chatila , Jun Liao , Liping Tang

Posterior Capsule Opacification (PCO) is the most common complication associated with Intraocular Lens (IOL) implantation. Based on the assumption that the interactions between an IOL and the lens capsule (LC) may influence the extent of PCO formation, a new in vitro model was developed to quantify the adhesion force of an IOL to simulated LC using a custom-designed micro-force tester. Using this system, we examined the influence of temperature (room temperature vs. body temperature) and incubation time (0 vs. 24 h) on the adhesion force between IOLs and LCs. The results show that, in line with clinical observations of PCO incidence, the adhesion force increased at body temperature and with increase in incubation time in the following order, Acrylic foldable IOLs > Silicone IOLs > PMMA IOLs. By examining the changes of surface properties as a function of temperature and incubation time, we found that acrylic foldable IOLs showed the largest increase in their hydrophilicity and reported the lowest surface roughness in comparison to other IOL groups. Coincidentally, using a newly established macromolecular dye imaging system to simulate cell migration between IOLs and LC, we observed that the amount of macromolecular dye infiltration between IOLs and LCs was in the following order: PMMA IOLs > Silicone IOLs > Acrylic foldable IOLs. These results support a new potential mechanism that body temperature, incubation time, surface hydrophilicity and smoothness of IOLs greatly contribute to their tight binding to LCs and such tight binding may lead to reduced IOL: LC space, cell infiltration, and thus PCO formation.



中文翻译:

IOL 材料特性的时间和温度相关变化对 IOL 的影响:晶状体胶囊相互作用

后囊混浊 (PCO) 是与人工晶状体 (IOL) 植入相关的最常见并发症。基于人工晶状体和晶状体囊 (LC) 之间的相互作用可能影响 PCO 形成程度的假设,一种新的体外开发模型以使用定制设计的微力测试仪量化 IOL 对模拟 LC 的粘附力。使用该系统,我们检查了温度(室温与体温)和孵育时间(0 与 24 小时)对 IOL 和 LC 之间粘附力的影响。结果表明,与PCO发病率的临床观察一致,粘附力在体温和孵育时间的增加下依次增加,亚克力可折叠人工晶状体>硅胶人工晶状体>PMMA人工晶状体。通过检查表面特性随温度和孵育时间的变化,我们发现与其他 IOL 组相比,丙烯酸可折叠 IOL 的亲水性增加最大,表面粗糙度最低。巧合的是,使用新建立的大分子染料成像系统模拟IOLs和LC之间的细胞迁移,我们观察到IOLs和LCs之间的大分子染料浸润量按以下顺序排列:PMMA IOLs > Silicone IOLs > Acrylic foldable IOLs。这些结果支持了一种新的潜在机制,即体温、孵育时间、IOL 的表面亲水性和光滑度极大地促进了它们与 LC 的紧密结合,这种紧密结合可能导致 IOL 减少:LC 空间、细胞浸润,从而导致 PCO 形成。

更新日期:2021-09-06
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