Long non-coding RNAs (lncRNAs) are a series of non-coding RNAs that lack open reading frameworks. Accumulating evidence suggests important roles for lncRNAs in various diseases, including cancers. Recently, lncRNA H19 (H19) became a research focus due to its ectopic expression in human malignant tumors, where it functioned as an oncogene. Subsequently, H19 was confirmed to be involved in tumorigenesis and malignant progression in many tumors and had been implicated in promoting cell growth, invasion, migration, epithelial-mesenchymal transition, metastasis, and apoptosis. H19 also sequesters some microRNAs, facilitating a multilayer molecular regulatory mechanism. In this review, we summarize the abnormal overexpression of H19 in human cancers, which suggests wide prospects for further research into the diagnosis and treatment of cancers.

中文翻译：

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LncRNA H19：多种癌症中的新癌基因

长链非编码 RNA (lncRNA) 是一系列缺乏开放阅读框架的非编码 RNA。越来越多的证据表明 lncRNA 在包括癌症在内的各种疾病中发挥着重要作用。最近，lncRNA H19（H19）因其在人类恶性肿瘤中的异位表达而成为研究热点，并在其中起到癌基因的作用。随后，H19 被证实与许多肿瘤的肿瘤发生和恶性进展有关，并与促进细胞生长、侵袭、迁移、上皮-间质转化、转移和凋亡有关。H19 还隔离一些 microRNA，促进多层分子调控机制。在这篇综述中，我们总结了人类癌症中 H19 的异常过表达，这为进一步研究癌症的诊断和治疗提供了广阔的前景。