The treatment of obesity based only on lifestyle changes has been shown ineffectiveness in a long-term period. The development of more definitive and non-invasive therapies has been the subject of study. In this paper, a magnetically driven ingestible capsule with the capacity to inflate a gastric balloon is devised, simulated, and fabricated. The balloon is inflated to a volume of 150 ml using an acid-base reaction between citric acid and potassium bicarbonate. Finite element method simulations were performed to study the interaction between the permanent external magnet and the ingestible capsule and confirm the magnetic activation mechanism. A fabrication process was proposed to manufacture a polydimethylsiloxane (PDMS) balloon in a simple, functional, and reproducible way. The two layers and 1:8 ratio balloons are the most cost-effective without compromising their mechanical properties. The capsule body parts manufactured by a three-dimensional (3D) printing process - Digital Light Processing (DLP) showed high accuracy and excellent resolution. This study demonstrated that the proposed ingestible capsule would successfully inflate the gastric balloon to treat obesity.

仅基于生活方式改变的肥胖治疗已被证明在长期内是无效的。开发更明确和非侵入性的疗法一直是研究的主题。在本文中，设计、模拟和制造了一种能够使胃气球膨胀的磁驱动可摄入胶囊。使用柠檬酸和碳酸氢钾之间的酸碱反应将球囊充气至 150 毫升的体积。进行了有限元方法模拟，以研究永久外磁体与可摄入胶囊之间的相互作用，并确认磁激活机制。提出了一种制造工艺，以简单、实用且可重复的方式制造聚二甲基硅氧烷 (PDMS) 球囊。两层和1：8 比例气球是最具成本效益的，而不会影响其机械性能。通过三维 (3D) 打印工艺 - 数字光处理 (DLP) 制造的胶囊主体部分显示出高精度和出色的分辨率。这项研究表明，所提出的可摄入胶囊可以成功地使胃球囊膨胀以治疗肥胖症。