Development of novel drugs or drug delivery systems has attracted much attention of researchers. In this study, we aimed to prepare 2 new Pt(II) complexes with thiosemicarbazone and their nanoformulations for cancer treatment application. Pt(II)-camphor thiosemicarbazone/P1 and Pt(II)-camphor 4-phenyl thiosemicarbazone/P2) were successfully prepared and structurally confirmed by MS, IR, 1H-NMR, UV–vis spectroscopies and thermal analysis. From the complexes, 2 PLGA-based nanoformulations (nP1 and nP2) were synthesised with the average size of 50 nm by emulsification/evaporation method and investigated for their toxicity against Hep-G2, LU-1 and RD cancer cell lines. The results show that the Pt(II) complexes and their nanoformulations were potential for chemotherapy.

新型药物或给药系统的开发引起了研究人员的广泛关注。在这项研究中，我们旨在制备 2 种新型 Pt(II) 与缩氨基硫脲的配合物及其纳米制剂，用于癌症治疗应用。成功制备了 Pt(II)-樟脑缩氨基硫脲/P1 和 Pt(II)-樟脑 4-苯基缩氨基硫脲/P2)，并通过 MS、IR、1H-NMR、UV-vis 光谱和热分析对其结构进行了确认。从复合物中，通过乳化/蒸发方法合成了平均大小为 50 nm 的 2 种基于 PLGA 的纳米制剂（nP1 和 nP2），并研究了它们对 Hep-G2、LU-1 和 RD 癌细胞系的毒性。结果表明，Pt(II) 复合物及其纳米制剂具有用于化疗的潜力。