Herein we report the facile synthesis of copper oxide nanoparticles (CuO NPs) using Areca catechu leaf extract as a bio-reducing agent and capping agent via solution combustion synthesis. The formation, crystalline structure and morphology of as-prepared CuO NPs were confirmed using UV–visible spectroscopy, powder x-ray diffraction (XRD), energy dispersive x-ray spectroscopy (EDS), scanning electron microscopy (SEM), high resolution transmission electron microscopy (HR-TEM) and selected area electron diffraction (SAED) techniques. The powder XRD analysis confirmed the purity of the as-synthesised material and crystalline structure. SEM images revealed that the morphology of prepared CuO NPs is monoclinic phase in nature. This was further confirmed by observing TEM micrographs, which revealed the spherical nature of obtained material with an average size of particle between 10 and 25 nm. Further, the hypoglycaemic effect of CuO NPs was observed to be facilitated by impeding α-amylase, which also promoted glucose uptake by the yeast cells. In addition, CuO NPs showed significant antidiabetic activity. Obtained results suggest that the inhibition of α-amylase enzyme with IC₅₀ value 260.33 μg ml⁻¹ may be one of the feasible ways through which the CuO NPs exerts their hypoglycaemic effect. Furthermore, cytotoxic activity performed using CuO NPs against human lung cancer cell line (A549) proved that the prepared CuO NPs have significant anticancer activity with 8.84 μg ml⁻¹ at 50% inhibition concentration (IC₅₀ value).

在此，我们报告了使用槟榔儿茶轻松合成氧化铜纳米颗粒 (CuO NPs)叶提取物通过溶液燃烧合成作为生物还原剂和封端剂。使用紫外-可见光谱、粉末 X 射线衍射 (XRD)、能量色散 X 射线光谱 (EDS)、扫描电子显微镜 (SEM)、高分辨率透射证实了所制备的 CuO NPs 的形成、晶体结构和形貌。电子显微镜 (HR-TEM) 和选区电子衍射 (SAED) 技术。粉末 XRD 分析证实了合成材料的纯度和晶体结构。SEM 图像显示所制备的 CuO NPs 的形态本质上是单斜相。通过观察 TEM 显微照片进一步证实了这一点，该照片揭示了所获得材料的球形特性，其平均颗粒尺寸在 10 到 25 nm 之间。更远，α-淀粉酶，它也促进酵母细胞对葡萄糖的吸收。此外，CuO NPs 显示出显着的抗糖尿病活性。所得结果表明，抑制α-淀粉酶的IC ₅₀值为260.33 μ g ml ^-1可能是CuO NPs发挥其降血糖作用的可行途径之一。此外，使用CuO NPs对人肺癌细胞系(A549)进行的细胞毒活性证明制备的CuO NPs具有显着的抗癌活性，在50%抑制浓度(IC ₅₀值)下为8.84 μ g ml ^-1。