Topical administration of various therapeutic factors at different stages of healing has the potential to enhance wound healing rates and reduce pain of chronic wounds. Here, the potential of utilising therapeutic fibres as wound dressings and/or sutures, is demonstrated by wet-spinning graphene oxide (GO) and aspirin adsorbed GO with polyvinyl alcohol, into drug eluting composite fibres. By varying the load of GO in the composite fibres it was possible to tailor strength, stiffness and stretchability. GO loadings of 5 wt.% resulted in fibres five times stronger than polyvinyl alcohol alone. Low loadings of GO 0.2–0.4 wt.% produced super-stretchable fibres. The drug loaded composite fibres exhibited a slow release of aspirin over a period of 3 d which is attributed to the π–π interactions between the GO and aspirin. These composite fibres demonstrate promise for incorporating other biological factors using GO as a vector, as well as creating textiles that can deliver therapeutics in a sustained manner, leading to flexible wearable therapeutics and sutures in the future.

在愈合的不同阶段局部施用各种治疗因子有可能提高伤口愈合率并减轻慢性伤口的疼痛。在这里，将治疗纤维用作伤口敷料和/或缝合线的潜力通过湿纺氧化石墨烯 (GO) 和用聚乙烯醇吸附的阿司匹林 GO 制成药物洗脱复合纤维来证明。通过改变复合纤维中 GO 的负载，可以调整强度、刚度和拉伸性。5 重量％的 GO 负载导致纤维强度是单独的聚乙烯醇的五倍。GO 0.2-0.4 wt.% 的低负载量产生了超拉伸纤维。载药复合纤维在 3 d 内表现出阿司匹林的缓慢释放，这归因于 GO 和阿司匹林之间的 π-π 相互作用。