A 46-year-old man presented with worsening vision in the context of long-standing optic disc changes, bilateral sensorineural hearing loss, chronic aseptic meningitis, rash, arthralgia and raised inflammatory markers. The differential diagnoses of neoplasia, infection and inflammation are discussed. We highlight a condition that can present to adult neurologists, with successful diagnosis leading to targeted treatments that transform patient outcomes. This case was presented at the Association of British Neurologists Annual Meeting 2020 as a Clinicopathological Conference (CPC).

中文翻译：

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慢性脑膜和全身炎症导致视力丧失

一名 46 岁男性因长期视盘改变、双侧感觉神经性听力损失、慢性无菌性脑膜炎、皮疹、关节痛和炎症标志物升高而出现视力恶化。讨论了肿瘤、感染和炎症的鉴别诊断。我们强调了一种可以呈现给成年神经科医生的疾病，成功的诊断会导致有针对性的治疗，从而改变患者的预后。该病例在英国神经病学家协会 2020 年年会上作为临床病理学会议 (CPC) 提出。