As we write this edition of Airwaves, the UK has abandoned lockdown and is relying on a high immunisation uptake and a world beating test and trace programme to keep COVID-19 at bay. The immediate effects have been a “pingdemic” where keyworkers across the nation are asked to self-isolate by the NHS app and there are fears that supermarket shelves may soon be bare. The pages of the current issue of Thorax however are far from bare, with a sumptuous display of excellent science. This month’s Airwaves endeavours to provide comic relief while showcasing the very best we have to offer. A classic episode of the situation comedy (sitcom) Father Ted hinges around a visit to Craggy Island by the church hierarchy to upgrade the Holy Stone of Clonrichert to a “class 2 relic”. Ted and his companions debate what miracles would be required to upgrade the monument – including time travel and cloning dinosaurs. The effects of CFTR modulators in cystic fibrosis while perhaps not miraculous, have certainly been dramatic. But are they sustained? In this month’s journal Barry and colleagues ( see page 874 ) describe the effects of the CFTR modulator Ivacaftor over a 5 year period in 35 patients with the G551D mutation. After 6 months of therapy, FEV1 had increased by almost 10% from baseline however within 5 years FEV1 had returned to …

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本期亮点

在我们撰写本期 Airwaves 时，英国已放弃封锁，并依靠高免疫接种率和世界领先的测试和追踪计划来阻止 COVID-19。直接影响是一场“瘟疫”，NHS 应用程序要求全国各地的关键工作人员进行自我隔离，人们担心超市货架可能很快就会空无一人。然而，当前一期 Thorax 的页面远非光秃秃的，而是华丽地展示了优秀的科学。本月的 Airwaves 努力提供喜剧效果，同时展示我们所能提供的最好的东西。情景喜剧（情景喜剧）泰德神父的经典剧集围绕着教堂等级制度对崎岖岛的访问，将克朗里赫特的圣石升级为“2 级遗物”。泰德和他的同伴们争论升级纪念碑需要什么奇迹——包括时间旅行和克隆恐龙。CFTR 调节剂在囊性纤维化中的作用虽然可能并不神奇，但确实是引人注目的。但它们能持续吗？在本月的期刊中，Barry 及其同事（参见第 874 页）描述了 CFTR 调节剂 Ivacaftor 在 5 年内对 35 名 G551D 突变患者的影响。治疗 6 个月后，FEV1 比基线增加了近 10%，但在 5 年内 FEV1 又恢复到…… 但它们能持续吗？在本月的期刊中，Barry 及其同事（参见第 874 页）描述了 CFTR 调节剂 Ivacaftor 在 5 年内对 35 名 G551D 突变患者的影响。治疗 6 个月后，FEV1 比基线增加了近 10%，但在 5 年内 FEV1 又恢复到…… 但它们能持续吗？在本月的期刊中，Barry 及其同事（参见第 874 页）描述了 CFTR 调节剂 Ivacaftor 在 5 年内对 35 名 G551D 突变患者的影响。治疗 6 个月后，FEV1 比基线增加了近 10%，但在 5 年内 FEV1 又恢复到……