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A phosphorescent probe for in vivo imaging in the second near-infrared window
Nature Biomedical Engineering ( IF 28.1 ) Pub Date : 2021-08-12 , DOI: 10.1038/s41551-021-00773-2
Baisong Chang 1, 2 , Daifeng Li 2, 3 , Ying Ren 2 , Chunrong Qu 4 , Xiaojing Shi 5 , Ruiqi Liu 6 , Hongguang Liu 6 , Jie Tian 5 , Zhenhua Hu 5 , Taolei Sun 1 , Zhen Cheng 2, 4
Affiliation  

In the second near-infrared spectral window (NIR-II; with wavelengths of 1,000–1,700 nm), in vivo fluorescence imaging can take advantage of reduced tissue autofluorescence and lower light absorption and scattering by tissue. Here, we report the development and in vivo application of a NIR-II phosphorescent probe that has lifetimes of hundreds of microseconds and a Stokes shift of 430 nm. The probe is made of glutathione-capped copper–indium–selenium nanotubes, and in acidic environments (pH 5.5–6.5) switches from displaying fluorescence to phosphorescence. In xenograft models of osteosarcoma and breast cancer, intravenous or intratumoral injections of the probe enabled phosphorescence imaging at signal-to-background ratios, spatial resolutions and sensitivities higher than NIR-II fluorescence imaging with polymer-stabilized copper–indium–sulfide nanorods. Phosphorescence imaging may offer superior imaging performance for a range of biomedical uses.



中文翻译:

用于在第二个近红外窗口中进行体内成像的磷光探针

在第二个近红外光谱窗口(NIR-II;波长为 1,000–1,700 nm)中,体内荧光成像可以利用减少的组织自发荧光和较低的组织光吸收和散射。在这里,我们报告了 NIR-II 磷光探针的开发和体内应用,该探针具有数百微秒的寿命和 430 nm 的斯托克斯位移。该探针由谷胱甘肽封端的铜-铟-硒纳米管制成,在酸性环境(pH 值 5.5-6.5)中从显示荧光切换为磷光。在骨肉瘤和乳​​腺癌的异种移植模型中,探针的静脉内或肿瘤内注射能够以信号背景比实现磷光成像,空间分辨率和灵敏度高于使用聚合物稳定的铜-铟-硫化物纳米棒进行的 NIR-II 荧光成像。磷光成像可为一系列生物医学用途提供卓越的成像性能。

更新日期:2021-08-12
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