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Enantio- and Regioselective Palladium(II)-Catalyzed Dioxygenation of (Aza-)Alkenols
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2021-08-13 , DOI: 10.1002/anie.202109312 Sabrina Giofrè 1 , Letizia Molteni 1 , Donatella Nava 1 , Leonardo Lo Presti 2 , Egle Maria Beccalli 1
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2021-08-13 , DOI: 10.1002/anie.202109312 Sabrina Giofrè 1 , Letizia Molteni 1 , Donatella Nava 1 , Leonardo Lo Presti 2 , Egle Maria Beccalli 1
Affiliation
An oxidative Pd-catalyzed intra-intermolecular dioxygenation of (aza-)alkenols has been reported, with total regioselectivity. To study the stereoselectivity, different chiral ligands as well as different hypervalent-iodine compounds have been compared. In particular, by using a C-6 modified pyridinyl-oxazoline (Pyox) ligand and hypervalent iodine bearing an aromatic ring, an excellent enantio- and diastereoselectivity has been achieved.
中文翻译:
(Aza-) 烯醇的对映选择性和区域选择性钯 (II) 催化双氧合
已经报道了氧化钯催化的(氮杂-)烯醇的分子间双氧合,具有总区域选择性。为了研究立体选择性,比较了不同的手性配体以及不同的高价碘化合物。特别是,通过使用 C-6 修饰的吡啶基-恶唑啉 (Pyox) 配体和带有芳香环的高价碘,实现了优异的对映选择性和非对映选择性。
更新日期:2021-09-20
中文翻译:
(Aza-) 烯醇的对映选择性和区域选择性钯 (II) 催化双氧合
已经报道了氧化钯催化的(氮杂-)烯醇的分子间双氧合,具有总区域选择性。为了研究立体选择性,比较了不同的手性配体以及不同的高价碘化合物。特别是,通过使用 C-6 修饰的吡啶基-恶唑啉 (Pyox) 配体和带有芳香环的高价碘,实现了优异的对映选择性和非对映选择性。