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Recent update of 3D printing technology in pharmaceutical formulation development
Journal of Biomaterials Science, Polymer Edition ( IF 3.6 ) Pub Date : 2021-08-26 , DOI: 10.1080/09205063.2021.1967702
Gaurav 1 , Nazeer Hasan 2 , Ankit Kumar Malik 3 , Vanshikha Singh 2 , Kaisar Raza 4 , Farhan J Ahmad 2 , Prashant Kesharwani 2 , Gaurav K Jain 1
Affiliation  

Abstract

In modern world, Pharma sector observes steep increase in demand of personalized medicine. Various unique ideas and technology were proposed and implemented by different researchers to prepare personalized medicine and devices. 3-dimensional printing (3DP) is one of the revolutionary technologies which can be used to prepare tailored medicine via CAD (Computer Aided Design) software. 3DP allows researchers to manufacture customized dosage form with desired modifications in geometry which would in turn alter dosage behaviour of the product with reduced side effects. Current achievement of 3DP includes personalized and adjustable dosage form, multifunction drug delivery systems, medical devices, phantoms, and implants specific to patient anatomy. Additionally, 3DP is employed for preparing tailored regenerative medicines. This review focuses on 3DP use in pharmaceuticals including drug delivery systems and medical devices with their method of fabrication. Additionally, different clinical trials as well as different patents done till date are cited in the paper. Furthermore, regulatory issues and future perspective related to 3 D printing is also well discussed.



中文翻译:

3D打印技术在药物制剂开发中的最新进展

摘要

在现代世界中,制药行业对个性化医疗的需求急剧增加。不同的研究人员提出并实施了各种独特的想法和技术,以制备个性化的药物和设备。3维印刷(3DP)是可用于制备药物定制革命性技术之一经由CAD(计算机辅助设计)软件。3DP 允许研究人员制造具有所需几何形状修改的定制剂型,这反过来会改变产品的剂量行为并减少副作用。3DP 目前的成就包括个性化和可调节的剂型、多功能给药系统、医疗设备、体模和特定于患者解剖结构的植入物。此外,3DP 用于制备定制的再生药物。本综述重点关注 3DP 在药物中的应用,包括药物输送系统和医疗设备及其制造方法。此外,论文中还引用了不同的临床试验以及迄今为止完成的不同专利。此外,与 3D 打印相关的监管问题和未来前景也得到了很好的讨论。

更新日期:2021-08-26
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