Chronic Pseudomonas aeruginosa (Pa) infection is associated with increased morbidity and mortality in people with cystic fibrosis (CF). There is no gold standard definition of chronic Pa infection in CF. We compared chronic Pa definitions using encounter-based versus annualized data in the Early Pseudomonas Infection Control (EPIC) Observational study cohort, and subsequently compared annualized chronic Pa definitions across a range of U.S. cohorts spanning decades of CF care. We found that an annualized chronic Pa definition requiring at least 1 Pa+ culture in 3 of 4 consecutive years (“Green 3/4”) resulted in chronic Pa metrics similar to established encounter-based modified Leeds criteria definitions, including a similar age at and proportion who fulfilled chronic Pa criteria, and a similar proportion with sustained Pa infection after meeting the chronic Pa definition. The Green 3/4 chronic Pa definition will be valuable for longitudinal analyses in cohorts with limited culture frequency.

慢性铜绿假单胞菌(Pa) 感染与囊性纤维化 (CF) 患者的发病率和死亡率增加有关。CF 中慢性 Pa 感染没有金标准定义。我们在早期假单胞菌感染控制 (EPIC) 观察研究队列中使用基于遭遇的数据与年度数据比较了慢性 Pa 定义，随后比较了跨越数十年 CF 护理的一系列美国队列的年度慢性 Pa 定义。我们发现，在连续 4 年中的 3 年（“绿色 3/4”）中需要至少 1 Pa+ 培养的年度慢性 Pa 定义导致慢性 Pa 指标类似于已建立的基于遭遇的修改利兹标准定义，包括相似的年龄和符合慢性 Pa 标准的比例，以及在满足慢性 Pa 定义后持续感染 Pa 的比例相似。