Chronic inflammation, including among people with HIV (PWH), elevates immune cell expression of lymphocyte activation gene 3 (LAG3); however, low plasma LAG3 predicts cardiovascular disease (CVD) events in the general population. The associations among LAG3 plasma levels, subclinical atherosclerosis, inflammation, and HIV infection have not been well described. We measured plasma LAG3 in 704 men with and without HIV from the multicenter AIDS cohort study, who underwent coronary computed tomography angiography. HIV serostatus was not independently associated with LAG3 after adjustment for sociodemographic and CVD risk factors. Current smoking status and African American race were associated with lower LAG3, and age and sTNFαRI concentration were associated with greater LAG3. LAG3 was not associated with coronary artery stenosis. Thus, no difference was found in plasma LAG3 concentration by HIV serostatus, and no association between LAG3 and subclinical coronary atherosclerosis in men with and without HIV was observed.

中文翻译：

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简短交流：多中心 AIDS 队列研究中的血浆淋巴细胞激活基因 3 和亚临床冠状动脉疾病

慢性炎症，包括 HIV 感染者 (PWH)，会提高淋巴细胞激活基因 3 (LAG3) 的免疫细胞表达；然而，低血浆 LAG3 可预测普通人群的心血管疾病 (CVD) 事件。LAG3 血浆水平、亚临床动脉粥样硬化、炎症和 HIV 感染之间的关联尚未得到很好的描述。我们测量了来自多中心 AIDS 队列研究的 704 名感染和未感染 HIV 的男性的血浆 LAG3，他们接受了冠状动脉计算机断层扫描血管造影。在调整社会人口学和心血管疾病危险因素后，艾滋病毒血清状况与 LAG3 无关。目前的吸烟状况和非裔美国人种族与较低的 LAG3 相关，而年龄和 sTNFαRI 浓度与较高的 LAG3 相关。LAG3 与冠状动脉狭窄无关。因此，