Purpose. To investigate the potential association between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with diabetic macular edema (DME). Methods. Participants in this cross-sectional study were 36 consecutive patients (36 eyes) with treatment-naïve DME, who underwent spectral domain-optical coherence tomography (SD-OCT), fundus photography, and fundus fluorescein angiography (FFA). In addition, peripheral blood samples were taken to evaluate full blood count and biochemical parameters. Correlation between imaging characteristics and laboratory parameters was examined. Results. Eyes with central subfield thickness greater than 405 μm presented significantly higher neutrophils/lymphocytes () and higher lipoprotein (a) compared to eyes with (). Presence of hyperreflective foci on SD-OCT was associated with significantly higher white blood cell count (). Ellipsoid zone disruption was associated with significantly lower hematocrit (), hemoglobin (), and red blood cell count (), as well as with higher lipoprotein (a) (). Macular ischemia on FFA was associated with significantly higher monocytes () and monocytes/HDL (). No significant associations were found between laboratory parameters and subretinal fluid, intraretinal fluid, exudates, cysts, disorganization of inner retinal layers, epiretinal membrane, and external limiting membrane condition. Conclusion. Specific imaging morphological characteristics were found to be associated with laboratory parameters in patients with DME. These findings may shed light on the pathophysiology of DME and its correlation with the development of specific clinical signs.

中文翻译：

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糖尿病性黄斑水肿患者影像学形态学发现与实验室生物标志物的相关性

目的。研究糖尿病黄斑水肿（DME）患者外周血生物标志物与视网膜成像形态学特征之间的潜在关联。方法。这项横断面研究的参与者是 36 名未接受过 DME 治疗的连续患者（36 只眼），他们接受了光谱域光学相干断层扫描 (SD-OCT)、眼底摄影和眼底荧光血管造影 (FFA)。此外，采集外周血样本以评估全血细胞计数和生化参数。检查了成像特征和实验室参数之间的相关性。结果。中央子区域厚度大于 405  μ m 的眼睛呈现出显着更高的中性粒细胞/淋巴细胞（)和更高的脂蛋白 (a) 与眼睛相比(）。SD-OCT 上存在高反射灶与显着升高的白细胞计数相关（）。椭球区破坏与显着降低的血细胞比容相关（),血红蛋白 ()和红细胞计数 ()，以及高脂蛋白 (a) (）。FFA 上的黄斑缺血与显着较高的单核细胞相关（)和单核细胞/HDL (）。实验室参数与视网膜下液、视网膜内液、渗出液、囊肿、视网膜内层紊乱、视网膜前膜和外界膜状况之间未发现显着关联。结论。发现特定的影像形态学特征与 DME 患者的实验室参数相关。这些发现可能有助于阐明 DME 的病理生理学及其与特定临床症状发展的相关性。