Background and Aims. This APOA5-1131C allele is related with a higher serum triglyceride levels and perhaps a different metabolic response to a dietary intervention. The aim of the present investigation was to evaluate SNP rs662799 in the APOA5 gene and its associations with metabolic effects after a hypocaloric diet with Mediterranean pattern. Methods. A population of 363 Caucasian obese patients was enrolled. Anthropometric parameters and serum parameters (lipid profile, insulin, homeostasis model assessment (HOMA-IR), glucose, C reactive protein, adiponectin, resistin, and leptin levels) were measured, at basal time and after 3 months. All patients were genotyped in the rs662799 polymorphism. Results. The APOA5 variant distribution was as follows: 89.3% () (TT) were homozygous for the T allele, 10.5% () (TC) were heterozygous, and 0.2% () (CC) were homozygous for the C allele. Triglyceride levels were higher in patients with the C allele. After dietary intervention, BMI, weight, fat mass, waist circumference, systolic blood pressure, adiponectin, leptin, and adiponectin/leptin ratio improved significantly in both genotype groups TT and TC+CC. After dietary intervention, insulin levels (delta: vs. ; ), HOMA-IR (delta: vs. ; ), and triglyceride levels (delta: vs. ; ) decreased in non-C allele carriers. Conclusions. C allele carriers of rs662799 of the APOA5 gene did not show an improvement in triglyceride, insulin, and HOMA-IR levels after a significant weight loss due to a hypocaloric diet with a Mediterranean pattern.

中文翻译：

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APOA-5 遗传变异 rs662799：在高加索肥胖受试者地中海饮食后脂质变化和胰岛素抵抗中的作用

背景和目标。这种 APOA5-1131C 等位基因与较高的血清甘油三酯水平有关，并且可能与对饮食干预的不同代谢反应有关。本研究的目的是评估APOA5基因中的 SNP rs662799及其与地中海模式低热量饮食后代谢效应的关联。方法。招募了 363 名高加索肥胖患者。在基础时间和 3 个月后测量人体测量参数和血清参数（脂质谱、胰岛素、稳态模型评估 (HOMA-IR)、葡萄糖、C 反应蛋白、脂联素、抵抗素和瘦素水平）。所有患者均在 rs662799 多态性中进行基因分型。结果。该APOA5 变异分布如下：89.3%（) (TT) 是 T 等位基因纯合子，10.5% () (TC) 是杂合子，0.2% () (CC) 是 C 等位基因的纯合子。C等位基因患者的甘油三酯水平较高。饮食干预后，TT和TC+CC基因型组的BMI、体重、脂肪量、腰围、收缩压、脂联素、瘦素和脂联素/瘦素比均显着改善。饮食干预后，胰岛素水平（δ： 对比 ; ), HOMA-IR (三角洲: 对比 ; )和甘油三酯水平 (delta: 对比 ; )在非 C 等位基因携带者中减少。结论。APOA5基因rs662799 的 C 等位基因携带者在由于地中海模式的低热量饮食导致体重显着减轻后，甘油三酯、胰岛素和 HOMA-IR 水平没有显示出改善。