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One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors.
Haematologica ( IF 10.1 ) Pub Date : 2022-05-01 , DOI: 10.3324/haematol.2021.279189
Dietger Niederwieser 1 , Helen Baldomero 2 , Nosa Bazuaye 3 , Caitrin Bupp 4 , Naeem Chaudhri 5 , Selim Corbacioglu 6 , Alaa Elhaddad 7 , Cristóbal Frutos 8 , Sebastian Galeano 9 , Nada Hamad 10 , Amir Ali Hamidieh 11 , Shahrukh Hashmi 12 , Aloysius Ho 13 , Mary M Horowitz 14 , Minako Iida 15 , Gregorio Jaimovich 16 , Amado Karduss 17 , Yoshihisa Kodera 15 , Nicolaus Kröger 18 , Regis Péffault de Latour 19 , Jong Wook Lee 20 , Juliana Martínez-Rolón 21 , Marcelo C Pasquini 14 , Jakob Passweg 22 , Kristjan Paulson 23 , Adriana Seber 24 , John A Snowden 25 , Alok Srivastava 26 , Jeff Szer 27 , Daniel Weisdorf 28 , Nina Worel 29 , Mickey B C Koh 30 , Mahmoud Aljurf 31 , Hildegard Greinix 32 , Yoshiko Atsuta 33 , Wael Saber 14
Affiliation  

The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers. In 2016, 82,718 first HCT were reported by 1,662 HCT teams in 86 of the 195 World Health Organization member states representing a global increase of 6.2% in autologous HCT and 7.0% in allogeneic HCT and bringing the total to 1,298,897 procedures. Assuming a frequency of 84,000/year, 1.5 million HCT were performed by 2019 since 1957. Slightly more autologous (53.5%) than allogeneic and more related (53.6%) than unrelated HCT were reported. A remarkable increase was noted in haploidentical related HCT for leukemias and lymphoproliferative diseases, but even more in non-malignant diseases. Transplant rates (TR; HCT/10 million population) varied according to region reaching 560.8 in North America, 438.5 in Europe, 76.7 in Latin America, 53.6 in South East Asia/Western Pacific (SEA/WPR) and 27.8 in African/East Mediterranean (AFR/EMR). Interestingly, haploidentical TR amounted to 32% in SEA/WPR and 26% in Latin America, but only 14% in Europe and EMR and 4.9% in North America of all allogeneic HCT. HCT team density (teams/10 million population) was highest in Europe (7.7) followed by North America (6.0), SEA/WPR (1.9), Latin America (1.6) and AFR/EMR (0.4). HCT are increasing steadily worldwide with narrowing gaps between regions and greater increase in allogeneic compared to autologous activity. While related HCT is rising, largely due to increase in haploidentical HCT, unrelated HCT is plateauing and cord blood HCT is in decline.

中文翻译:

150 万次造血干细胞移植:使用不同的家庭供体在全球范围内获得持续和差异化的改善。

全球血液和骨髓移植网络 (WBMT) 追求促进造血细胞移植 (HCT) 的使命,例如通过评估成员协会、国家登记处和个别中心的活动。2016 年,世界卫生组织 195 个成员国中的 86 个国家的 1,662 个 HCT 团队报告了 82,718 例首次 HCT,这意味着全球自体 HCT 和异体 HCT 增长了 6.2%,同种异体 HCT 增长了 7.0%,总数达到 1,298,897 例。假设频率为 84,000/年,自 1957 年以来,到 2019 年进行了 150 万次 HCT。据报道,自体 HCT (53.5%) 略高于同种异体,相关 HCT (53.6%) 高于无关 HCT。白血病和淋巴增生性疾病的单倍体相关 HCT 显着增加,但在非恶性疾病中甚至更多。移植率(TR;HCT/1000 万人口)因地区而异,北美为 560.8,欧洲为 438.5,拉丁美洲为 76.7,东南亚/西太平洋 (SEA/WPR) 为 53.6,非洲/东地中海为 27.8 (AFR/电子病历)。有趣的是,在所有异基因 HCT 中,单倍体 TR 在 SEA/WPR 中达到 32%,在拉丁美洲达到 26%,但在欧洲和 EMR 中仅为 14%,在北美仅为 4.9%。HCT 团队密度(团队/1000 万人口)在欧洲(7.7)最高,其次是北美(6.0)、SEA/WPR(1.9)、拉丁美洲(1.6)和 AFR/EMR(0.4)。与自体活动相比,HCT 在全球范围内稳步增长,区域之间的差距缩小,同种异体的增加更大。虽然相关的 HCT 正在上升,主要是由于单倍体 HCT 的增加,但不相关的 HCT 处于平稳状态,而脐带血 HCT 正在下降。HCT/1000 万人口)因地区而异,北美为 560.8,欧洲为 438.5,拉丁美洲为 76.7,东南亚/西太平洋 (SEA/WPR) 为 53.6,非洲/东地中海 (AFR/EMR) 为 27.8 . 有趣的是,在所有异基因 HCT 中,单倍体 TR 在 SEA/WPR 中达到 32%,在拉丁美洲达到 26%,但在欧洲和 EMR 中仅为 14%,在北美仅为 4.9%。HCT 团队密度(团队/1000 万人口)在欧洲(7.7)最高,其次是北美(6.0)、SEA/WPR(1.9)、拉丁美洲(1.6)和 AFR/EMR(0.4)。与自体活动相比,HCT 在全球范围内稳步增长,区域之间的差距缩小,同种异体的增加更大。虽然相关的 HCT 正在上升,主要是由于单倍体 HCT 的增加,但不相关的 HCT 处于平稳状态,而脐带血 HCT 正在下降。HCT/1000 万人口)因地区而异,北美为 560.8,欧洲为 438.5,拉丁美洲为 76.7,东南亚/西太平洋 (SEA/WPR) 为 53.6,非洲/东地中海 (AFR/EMR) 为 27.8 . 有趣的是,在所有异基因 HCT 中,单倍体 TR 在 SEA/WPR 中达到 32%,在拉丁美洲达到 26%,但在欧洲和 EMR 中仅为 14%,在北美仅为 4.9%。HCT 团队密度(团队/1000 万人口)在欧洲(7.7)最高,其次是北美(6.0)、SEA/WPR(1.9)、拉丁美洲(1.6)和 AFR/EMR(0.4)。与自体活动相比,HCT 在全球范围内稳步增长,区域之间的差距缩小,同种异体的增加更大。虽然相关的 HCT 正在上升,主要是由于单倍体 HCT 的增加,但不相关的 HCT 处于平稳状态,而脐带血 HCT 正在下降。
更新日期:2021-08-12
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