This article aims to provide a comprehensive review of Cissus quadrangularis (CQ), which is a traditional medicinal herb and has a potential osteoprotective effect. CQ is a perennial climber of family Vitaceae that is commonly found in the hotter parts of India. It is most widely used in India for improving bone health and is well known as "hadjod." It shows an anti-osteoporotic effect through different pathways mechanisms. It is natural matrices of excellence with proven bioactivity. Several cell line and animal studies demonstrated its protective nature against many diseases such as osteoporosis, arthritis, gastric ulcers etc. This review also highlights the phytochemicals identified to the date and related pharmacological applications. The discussion has also expanded to its oral formulations, which has been proven for its efficacy practically. However, the scientific information of CQ is not in the proper documentation for reference, and so availability of scientific knowledge of this climber is limited. Therefore, this review might be provided a platform to those who will be interested in studying further this herb, either for analyzing phytochemical profiling or its anti-osteoporotic usage. This is a crucial platform as several productive results have been reported on this herb, which likely to be beneficial for new drug discovery in future. Here we also discuss the bone remodeling and related factors influenced by the intake of CQ.

中文翻译：

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Cissus quadrangularis 在骨质疏松症管理中的作用：概述。

本文旨在对具有潜在骨保护作用的传统药草Cissus quadrangularis (CQ)进行全面综述。CQ 是葡萄科的多年生攀缘植物，常见于印度较热的地区。它在印度最广泛用于改善骨骼健康，被称为“hadjod”。它通过不同的途径机制显示出抗骨质疏松作用。它是具有经证实的生物活性的卓越天然基质。一些细胞系和动物研究证明了其对许多疾病（如骨质疏松症、关节炎、胃溃疡等）的保护性质。本综述还重点介绍了迄今为止确定的植物化学物质和相关药理学应用。讨论还扩展到其口服制剂，这已被实践证明其功效。但是，CQ 的科学信息不在适当的文档中以供参考，因此该登山者的科学知识的可用性是有限的。因此，这篇综述可能为那些有兴趣进一步研究这种草药的人提供一个平台，用于分析植物化学分析或其抗骨质疏松症的用途。这是一个重要的平台，因为已经报道了关于这种草药的几个富有成效的结果，这可能有利于未来的新药发现。在这里我们也讨论了摄入 CQ 影响的骨重建和相关因素。这篇综述可能为那些有兴趣进一步研究这种草药的人提供一个平台，用于分析植物化学分析或其抗骨质疏松症的用途。这是一个重要的平台，因为已经报道了关于这种草药的几个富有成效的结果，这可能有利于未来的新药发现。在这里我们也讨论了摄入 CQ 影响的骨重建和相关因素。这篇综述可能为那些有兴趣进一步研究这种草药的人提供一个平台，用于分析植物化学分析或其抗骨质疏松症的用途。这是一个重要的平台，因为已经报道了关于这种草药的几个富有成效的结果，这可能有利于未来的新药发现。在这里我们也讨论了摄入 CQ 影响的骨重建和相关因素。