How does the human brain prioritize different visual representations in working memory (WM)? Here, we define the oscillatory mechanisms supporting selection of "where" and "when" features from visual WM storage and investigate the role of pFC in feature selection. Fourteen individuals with lateral pFC damage and 20 healthy controls performed a visuospatial WM task while EEG was recorded. On each trial, two shapes were presented sequentially in a top/bottom spatial orientation. A retro-cue presented mid-delay prompted which of the two shapes had been in either the top/bottom spatial position or first/second temporal position. We found that cross-frequency coupling between parieto-occipital alpha (α; 8-12 Hz) oscillations and topographically distributed gamma (γ; 30-50 Hz) activity tracked selection of the distinct cued feature in controls. This signature of feature selection was disrupted in patients with pFC lesions, despite intact α-γ coupling independent of feature selection. These findings reveal a pFC-dependent parieto-occipital α-γ mechanism for the rapid selection of visual WM representations.

中文翻译：

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前额叶病变破坏视觉工作记忆表征的后部 Alpha-Gamma 协调。

人脑如何优先处理工作记忆 (WM) 中的不同视觉表征？在这里，我们定义了支持从视觉 WM 存储中选择“where”和“when”特征的振荡机制，并研究了 pFC 在特征选择中的作用。14 名侧前额叶皮质受损的人和 20 名健康对照者在记录脑电图的同时执行了视觉空间 WM 任务。在每个试验中，两个形状按顶部/底部空间方向顺序呈现。中间延迟出现的逆向提示提示两种形状中的哪一种处于顶部/底部空间位置或第一/第二时间位置。我们发现顶枕叶 alpha (α; 8-12 Hz) 振荡和地形分布的 gamma (γ; ) 之间存在交叉频率耦合。30-50 Hz) 活动跟踪控件中不同提示功能的选择。这种特征选择的特征在 pFC 病变患者中被破坏，尽管完整的 α-γ 耦合独立于特征选择。这些发现揭示了用于快速选择视觉 WM 表征的 pFC 依赖性顶枕叶 α-γ 机制。