The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB. Moreover, we discuss how to target IFNγ signaling to inform novel clinical trials to treat patients with colorectal cancer.

中文翻译：

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结直肠癌免疫和免疫治疗中 IFNγ 信号完整性

大多数结直肠癌患者对免疫检查点阻断（ICB）没有反应。干扰素 γ (IFNγ) 信号通路驱动自发的和 ICB 诱导的抗肿瘤免疫。在这篇综述中，我们总结了结直肠癌微环境中 IFNγ 信号通路的表观遗传、遗传和功能完整性的最新进展，及其与 ICB 治疗效果和耐药性的免疫学相关性。此外，我们还讨论了如何靶向 IFNγ 信号传导，为治疗结直肠癌患者的新临床试验提供信息。