Currently, reactive oxygen species (ROS) generation primarily depends upon light and O₂, which hampers its further biomedical application. Here, we report that a manganese(III) salen-based complex (MnS) can continuously catalyze overexpressed hydrogen peroxide (H₂O₂) in the tumor microenvironment to ¹O₂, while the nanocarrier (MIL-100) as a Fenton reagent can convert H₂O₂ to hydroxyl radicals (•OH) through the Fenton reaction, inducing noticeable intracellular DNA strand scission and lipid peroxidation to provoke tumor cell apoptosis without the involvement of light and O₂. Moreover, MIL-100 depleted the antioxidant glutathione, further amplifying intracellular oxidative pressure, which in turn led to the self-degradation of MIL-100, suggesting the long-term biosafety of the nanoplatform. Owing to the excellent magnetic resonance imaging performance of MnS, the diagnosis and specific treatment of tumors were eventually achieved. This work provides a novel approach for the realization of effective tumor catalytic therapy independent of light and O₂ and a promising reference for the development of a wide range of catalytic therapeutic agents.

目前，活性氧 (ROS) 的产生主要依赖于光和 O ₂，这阻碍了其进一步的生物医学应用。在这里，我们报告了基于锰 (III) 沙伦的复合物 (MnS) 可以连续将肿瘤微环境中过表达的过氧化氢 (H ₂ O ₂ )催化为¹ O ₂，而纳米载体 (MIL-100) 作为 Fenton 试剂可通过芬顿反应将H ₂ O ₂转化为羟基自由基（•OH），诱导细胞内明显的DNA链断裂和脂质过氧化，在无光和O ₂参与的情况下引发肿瘤细胞凋亡. 此外，MIL-100 耗尽抗氧化剂谷胱甘肽，进一步放大细胞内氧化压力，进而导致 MIL-100 的自我降解，表明纳米平台的长期生物安全性。由于MnS优异的磁共振成像性能，最终实现了肿瘤的诊断和特异性治疗。这项工作为实现独立于光和O ₂的有效肿瘤催化治疗提供了一种新方法，并为开发各种催化治疗剂提供了有希望的参考。