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A New Fusicoccane-Type Norditerpene and a New Indone from the Marine-Derived Fungus Aspergillus aculeatinus WHUF0198
Chemistry & Biodiversity ( IF 2.9 ) Pub Date : 2021-08-11 , DOI: 10.1002/cbdv.202100562
Jun Wu 1 , Hong Zhang 2 , Li-Ming He 1 , Ya-Qing Xue 1 , Jia Jia 3 , Shou-Bao Wang 4 , Kong-Kai Zhu 5 , Kui Hong 1 , You-Sheng Cai 1
Affiliation  

A new norditerpene named aculeaterpene A (1) and a new indone named aculeaindone A (2), along with eight known compounds 310 were isolated from the culture extract of Aspergillus aculeatinus WHUF0198. The structural characterization of compounds 1 and 2 were performed by spectroscopic analysis, including 1D and 2D NMR and HR-ESI-MS experiments, whereas the absolute configurations were determined by comparing their experimental or calculated ECD spectra. Compound 1 was the first report of fusicoccane-based norditerpene, in which the C-20 was degraded and tured into a hydroxy group.

中文翻译:

来自海洋源真菌棘孢曲霉 WHUF0198 的新型 Fusicoccane 型北二萜和新型吲哚

棘孢曲霉WHUF0198的培养物提取物中分离出一种名为 aculeaterpene A ( 1 ) 的新降二萜和一种名为 aculeaindone A ( 2 )的新吲哚,以及八种已知化合物3 - 10。化合物12的结构表征是通过光谱分析进行的,包括 1D 和 2D NMR 和 HR-ESI-MS 实验,而绝对构型是通过比较它们的实验或计算的 ECD 光谱来确定的。化合物1是首次报道的以褐藻胶为基础的降二萜,其中 C-20 被降解并转化为羟基。
更新日期:2021-10-19
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