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Mixed Solvent Method for Improving the Size Uniformity and Cargo-Loading Efficiency of ZIF-8 Nanoparticles
Langmuir ( IF 3.9 ) Pub Date : 2021-08-12 , DOI: 10.1021/acs.langmuir.1c01399
Heze Guo 1 , Lingshan Liu 1 , Qiangqiang Hu 1 , Hongjing Dou 1
Affiliation  

Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles with tunable diameters and a uniform morphology were constructed in dimethyl sulfoxide (DMSO)/H2O mixed solvents and were further decorated with dextran to improve their stability and biocompatibility. A series of reaction conditions, including the DMSO content in mixed solvents, molar ratio between precursors, growth time, and decoration of dextran, were systematically investigated. Most importantly, it was the union of DMSO and water that achieved the combined merits of both solvothermal and hydrothermal methods, namely, high uniformity and high efficiency, respectively. In addition, numerous properties of these ZIF-8 nanoparticles were subsequently studied, such as the crystal structure, surface properties, and porosity. Furthermore, composite ZIF-8 nanoparticles encapsulating various functional molecules were also successfully prepared in the same DMSO/H2O mixed solvents, thus laying the foundation for their application as nanocarriers in the biomedical field.

中文翻译:

提高ZIF-8纳米颗粒尺寸均匀性和载货效率的混合溶剂法

在二甲基亚砜 (DMSO)/H 2中构建了具有可调直径和均匀形态的沸石咪唑酯骨架 8 (ZIF-8) 纳米粒子O 混合溶剂并进一步用葡聚糖修饰以提高其稳定性和生物相容性。系统研究了一系列反应条件,包括混合溶剂中 DMSO 的含量、前驱体之间的摩尔比、生长时间和葡聚糖的修饰。最重要的是,DMSO 和水的结合实现了溶剂热法和水热法的综合优点,即高均匀性和高效率。此外,随后研究了这些 ZIF-8 纳米粒子的许多特性,例如晶体结构、表面特性和孔隙率。此外,在相同的DMSO/H 2中也成功制备了包封各种功能分子的复合ZIF-8纳米颗粒。O 混合溶剂,从而为其在生物医学领域作为纳米载体的应用奠定了基础。
更新日期:2021-08-24
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