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Sequence-Defined Synthetic Polymers for New-Generation Functional Biomaterials
ACS Materials Letters ( IF 11.4 ) Pub Date : 2021-08-12 , DOI: 10.1021/acsmaterialslett.1c00358
Zhengyu Deng 1 , Qiangqiang Shi 1 , Jiajia Tan 1 , Jinming Hu 1 , Shiyong Liu 1
Affiliation  

Synthetic polymers have been extensively exploited for biomedical and pharmacological applications, spanning from surgical devices, diagnostics, tissue engineering, regenerative medicine, to drug delivery systems. However, a fundamental and quantitative correlation between the primary chemical structures of polymeric biomaterials and the resulting biological responses remains elusive. Encouragingly, the advent and development of sequence-defined polymers (SDPs) provide an unprecedented opportunity to precisely tune their sequence information, intrachain folding, interchain self-assembly, and macroscopic properties, enabling the elucidation of the structure–property relationship of biomaterials. In this Perspective, we highlight recent advances of SDPs as next-generation functional biomaterials, and their potential applications in antimicrobial agents, bioactive ligands, precision drug delivery systems, bioimaging agents, and barcoded biomaterials, from sequence-defined synthetic oligomers and polymers. Finally, we present a critical outlook on the challenges in the design and development of SDP-based emergent biomaterials.

中文翻译:

用于新一代功能性生物材料的序列定义合成聚合物

合成聚合物已被广泛用于生物医学和药理学应用,从手术设备、诊断、组织工程、再生医学到药物输送系统。然而,聚合物生物材料的主要化学结构与由此产生的生物反应之间的基本和定量相关性仍然难以捉摸。令人鼓舞的是,序列定义聚合物(SDPs)的出现和发展为精确调整其序列信息、链内折叠、链间自组装和宏观特性提供了前所未有的机会,从而能够阐明生物材料的结构-特性关系。在这个观点中,我们强调了 SDP 作为下一代功能性生物材料的最新进展,以及它们在抗菌剂、生物活性配体、精密药物递送系统、生物成像剂和条形码生物材料中的潜在应用,来自序列定义的合成低聚物和聚合物。最后,我们对基于 SDP 的新兴生物材料的设计和开发中的挑战提出了批判性的看法。
更新日期:2021-09-06
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