Objective Periodontitis has been independently associated to cardiovascular disease. However, the biological mechanisms underlying such association are still partially unknown. Thus, this study aimed to discover immunological clues accounting for the increased risk of myocardial infarction (MI) in patients having periodontitis. Methods We included 100 patients with a first MI, 50 with and 50 without severe periodontitis, and 100 age-matched, sex-matched and area-matched controls from the Periodontitis and Its Relation to Coronary Artery Disease Study. Participants underwent comprehensive clinical and laboratory examinations 6–10 weeks after the MI and plasma expression of 92 inflammation-related markers was assessed through proximity extension assay. Results Patients who had an MI displayed altered expression of CCL19, TNFRSF9 and LAP TGF-β1 in comparison with controls. TNFRSF9 correlated significantly with the amount of alveolar bone loss. MI patients with deep periodontal pockets showed increased white cell count and higher expression of FGF-21, HGF, OSM, CCL20 and IL-18R1 than patients without. White cell count correlated significantly with four of these proteins. Conclusions Collectively, our results indicate molecular markers that could be responsible for the increased systemic inflammatory activity in patients with MI with periodontitis. Data are available on reasonable request.

中文翻译：

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牙周炎与心肌梗死后患者的全身炎症增加有关

目的牙周炎与心血管疾病独立相关。然而，这种关联背后的生物学机制仍然部分未知。因此，本研究旨在发现导致牙周炎患者心肌梗塞 (MI) 风险增加的免疫学线索。方法 我们纳入了来自牙周炎及其与冠状动脉疾病研究的 100 名首次 MI 患者、50 名患有和 50 名没有严重牙周炎的患者，以及 100 名年龄匹配、性别匹配和区域匹配的对照。参与者在 MI 后 6-10 周接受了全面的临床和实验室检查，并通过邻近延伸试验评估了 92 种炎症相关标志物的血浆表达。结果 患有 MI 的患者表现出 CCL19 的表达改变，TNFRSF9 和 LAP TGF-β1 与对照相比。TNFRSF9 与牙槽骨丢失量显着相关。与没有牙周袋的 MI 患者相比，具有深牙周袋的 MI 患者的白细胞计数增加，FGF-21、HGF、OSM、CCL20 和 IL-18R1 的表达更高。白细胞计数与这些蛋白质中的四种显着相关。结论 总的来说，我们的结果表明分子标志物可能是导致患有牙周炎的 MI 患者全身炎症活动增加的原因。可应合理要求提供数据。白细胞计数与这些蛋白质中的四种显着相关。结论 总的来说，我们的结果表明分子标志物可能是导致患有牙周炎的 MI 患者全身炎症活动增加的原因。可应合理要求提供数据。白细胞计数与这些蛋白质中的四种显着相关。结论 总的来说，我们的结果表明分子标志物可能是导致患有牙周炎的 MI 患者全身炎症活动增加的原因。可应合理要求提供数据。