Background

Advanced interatrial block (IAB) is present in 10% of subjects ≥75 years and is associated with the risk of clinical events.

Methods and results

Prospective multicenter study that will include subjects ≥75 years without exclusion criteria (indication for anticoagulation, cardiac devices, severe valve disease, systolic dysfunction, moderate or severe cognitive impairment, poor echocardiographic window, non-sinus rhythm or partial IAB, stroke, and life expectancy <2 years). A total of 356 subjects, 178 patients with advanced IAB (exposed) and 178 matched individuals with normal P-wave (non-exposed) will be included. Electrocardiogram and advanced transthoracic echocardiography will be performed. Two substudies will include magnetic resonance imaging: cardiac (86 subjects, 43 exposed, and 43 non-exposed) and brain (86 subjects, 43 exposed, and 43 non-exposed). The follow-up will be 2 years. Our main objective is to determine the association of advanced IAB, P-wave duration, and atrial imaging parameters (I] atrial global longitudinal strain, II] maximal left atrial volume index, III] left atrial ejection fraction, IV] left atrial fibrosis - % total left atrial area V] inter- and intra-atrial asynchrony/dyssynchrony) with clinical events (atrial fibrillation, stroke, cognitive impairment, and mortality). The secondary objective is to assess the association of the P-wave duration with atrial imaging parameters and of both with cerebral microemboli in magnetic resonance imaging.

Conclusion

Our study will provide data regarding the association of advanced IAB, P-wave duration, and atrial imaging parameters with clinical events. We will also assess the association P-wave duration-atrial imaging parameters-cerebral microemboli.

中文翻译：

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晚期心房传导阻滞 (ARABIA) 前瞻性研究中严格心房分析的基本原理和设计

背景

10% ≥ 75 岁的受试者存在晚期心房传导阻滞 (IAB)，并且与临床事件的风险相关。

方法和结果

前瞻性多中心研究将纳入 75 岁以上且无排除标准的受试者（抗凝指征、心脏装置、严重瓣膜疾病、收缩功能障碍、中度或重度认知障碍、超声心动图窗口差、非窦性心律或部分 IAB、中风和生命预期 <2 年）。将包括总共 356 名受试者，178 名晚期 IAB 患者（暴露）和 178 名 P 波正常（未暴露）的匹配个体。将进行心电图和高级经胸超声心动图检查。两个子研究将包括磁共振成像：心脏（86 名受试者，43 名暴露，43 名未暴露）和大脑（86 名受试者，43 名暴露，43 名未暴露）。随访期为 2 年。我们的主要目标是确定晚期 IAB、P 波持续时间、和心房成像参数（I] 心房整体纵向应变，II] 最大左心房容积指数，III] 左心房射血分数，IV] 左心房纤维化 - 左心房总面积百分比 V] 心房间和心房内不同步/不同步）临床事件（心房颤动、中风、认知障碍和死亡率）。次要目的是评估 P 波持续时间与心房成像参数的关联，以及两者与磁共振成像中脑微栓子的关联。

结论

我们的研究将提供关于晚期 IAB、P 波持续时间和心房成像参数与临床事件之间的关联的数据。我们还将评估 P 波持续时间-心房成像参数-脑微栓子的关联。