Type 1 allergies, involve a complex interaction between dendritic cells and other immune cells, are pathological type 2 inflammatory immune responses against harmless allergens. Activated dendritic cells undergo extensive phenotypic and functional changes to exert their functions. The activation, differentiation, proliferation, migration, and mounting of effector reactions require metabolic reprogramming. Dendritic cells are important upstream mediators of allergic responses and are therefore an important effector of allergies. Hence, a better understanding of the underlying metabolic mechanisms of functional changes that promote allergic responses of dendritic cells could improve the prevention and treatment of allergies. Metabolic changes related to dendritic cell activation have been extensively studied. This review briefly outlines the basis of fatty acid oxidation and its association with dendritic cell immune responses. The relationship between immune metabolism and effector function of dendritic cells related to allergic diseases can better explain the induction and maintenance of allergic responses. Further investigations are warranted to improve our understanding of disease pathology and enable new treatment strategies.

中文翻译：

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脂肪酸氧化及其对过敏中树突状细胞介导的免疫反应的调节：免疫代谢的观点

1 型过敏涉及树突状细胞和其他免疫细胞之间的复杂相互作用，是针对无害过敏原的病理性 2 型炎症免疫反应。活化的树突细胞经历广泛的表型和功能变化以发挥其功能。效应反应的激活、分化、增殖、迁移和安装需要代谢重编程。树突状细胞是过敏反应的重要上游介质，因此是过敏的重要效应物。因此，更好地了解促进树突状细胞过敏反应的功能变化的潜在代谢机制可以改善过敏的预防和治疗。与树突状细胞活化相关的代谢变化已被广泛研究。本综述简要概述了脂肪酸氧化的基础及其与树突状细胞免疫反应的关联。免疫代谢与过敏性疾病相关树突状细胞效应功能的关系可以更好地解释过敏反应的诱导和维持。有必要进行进一步的调查，以提高我们对疾病病理学的理解并启用新的治疗策略。