The skin is the largest organ in the human body, and it orchestrates many functions that are fundamentally important for our survival. Although the skin might appear to present a relatively inhospitable or even hostile environment, a multitude of commensals and also some potentially pathogenic microorganisms have successfully adapted to survive and/or thrive within the diverse ecological niches created by the skin’s topographical architecture. Dysbiosis within these microbial populations can result in the emergence and pathological progression of skin diseases. Unsurprisingly, this has led to a new focus of research both for the medical dermatology and cosmetic industries that is concerned with modulation of the skin microbiome to help address common microbially mediated or modulated conditions such as acne, body odour, and atopic dermatitis. This review presents an overview of our current understanding of the complex relationship of the skin with its microbiome and then introduces the concept of probiotic intervention for the management of microbial dysbiosis within the skin ecosystem.

皮肤是人体最大的器官，它协调许多对我们的生存至关重要的功能。尽管皮肤可能呈现出相对不适宜甚至敌对的环境，但大量的共生体以及一些潜在的致病微生物已经成功地适应了在由皮肤的地形结构创造的不同生态位中生存和/或繁衍。这些微生物种群内的生态失调可导致皮肤病的出现和病理进展。不出所料，这为医学皮肤病学和化妆品行业带来了一个新的研究重点，即关注皮肤微生物组的调节，以帮助解决常见的微生物介导或调节的疾病，如痤疮、体臭和特应性皮炎。