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Synthesis, spectral characterization, thermo-kinetic and biological studies of some complexes derived from tridentate hydrazone Schiff base
Journal of Saudi Chemical Society ( IF 5.6 ) Pub Date : 2021-08-11 , DOI: 10.1016/j.jscs.2021.101325
Gajanan Dongare 1 , Anand Aswar 1
Affiliation  

New Schiff base hydrazone ligand 2-hydroxybenzylidene-4-oxopiperidine-1-carbohydrazone (H2L) was designed and synthesized by the condensation of 4-oxo-1-carbopiperidone hydrazide with 2-hydroxy benzaldehyde. This ligand reacts with chloride salts of Cr(III), Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) to give complexes [Cr(L)(H2O)2Cl] (1), [Mn(HL)(H2O)2Cl] (2), [Fe(L)(H2O)2Cl] (3), [Co(HL)(H2O)2Cl] (4), [Ni(HL)(H2O)2Cl], (5), and [Cu(HL)(H2O)2Cl] (6), respectively. The ligand was characterized by elemental and spectral (viz. IR, UV–vis, 1H NMR and 13C NMR, mass) analyses and complexes were additionally characterized by molar conductance, magnetic susceptibility measurements, ESR, powder XRD, SEM and TG analyses. The analytical data suggest 1:1 (M: L) stoichiometric for all the complexes. The ligand behaves as a dibasic tridentate, coordinating through the Ophenolate, Nazomethine, Oenolate donor functionality towards the Cr(III) and Fe(III) ion while it behaves as monobasic tridentate and coordinates through Ophenolate, Nazomethine, Oketonic in other complexes. Physicochemical data suggests an octahedral geometry for all complexes. SEM analysis revealed regular, uniform morphological size of ligand but varies in its complexes. ESR studies confirmed that stronger covalency character in π- bonding than σ bonding. X-ray diffraction study confirms semi crystalline nature of ligand and its metal complexes. Thermal behavior (TG/DTA) and kinetic parameters calculated by Coats- Redfern method suggest more ordered activated state in complex formation. The ligand and its complexes were screened for antibacterial activity against gram-negative bacteria (Escherichia coli and S. typhi), gram-positive bacteria (Staphylococcus aureus and Bacillus substillus) and the fungal activity against pathogens (Candida albicans and Aspergillus niger) and obtained data show that metal complexes are more potent than the parent ligand against bacterial species.



中文翻译:

三齿腙席夫碱衍生的一些配合物的合成、光谱表征、热动力学和生物学研究

通过4-oxo-1-carbopiperidone hydrazide与2-羟基苯甲醛缩合,设计并合成了新的席夫碱腙配体2-羟基苯亚甲基-4-氧代哌啶-1-碳腙(H 2 L)。该配体与 Cr(III)、Mn(II)、Fe(III)、Co(II)、Ni(II) 和 Cu(II) 的氯化物盐反应生成复合物 [Cr(L)(H 2 O) 2 Cl] ( 1 ), [Mn(HL)(H 2 O) 2 Cl] ( 2 ), [Fe(L)(H 2 O) 2 Cl] ( 3 ), [Co(HL)(H 2 O) 2 Cl] ( 4 ), [Ni(HL)(H 2 O) 2 Cl], ( 5) 和 [Cu(HL)(H 2 O) 2 Cl] ( 6 )。配体通过元素和光谱(即 IR、UV-vis、1 H NMR 和13 C NMR、质量)分析表征,配合物还通过摩尔电导、磁化率测量、ESR、粉末 XRD、SEM 和 TG 分析表征. 分析数据表明所有配合物的化学计量为 1:1 (M: L)。配体表现为二元三齿,通过 O酚盐、N偶氮甲碱、O烯醇化物供体官能团向 Cr(III) 和 Fe(III) 离子配位,而它表现为一元三齿并通过 O苯酚、N 配位偶氮甲碱,O在其他配合物中。物理化学数据表明所有配合物都具有八面体几何形状。SEM 分析揭示了配体的规则、均匀的形态大小,但其复合物有所不同。ESR 研究证实 π-键合比 σ 键合具有更强的共价特性。X 射线衍射研究证实了配体及其金属配合物的半结晶性质。通过 Coats-Redfern 方法计算的热行为 (TG/DTA) 和动力学参数表明复合物形成中的活化状态更有序。筛选配体及其复合物对革兰氏阴性菌(大肠杆菌伤寒杆菌)、革兰氏阳性菌(金黄色葡萄球菌金黄色葡萄球菌)的抗菌活性Bacillus substillus ) 和针对病原体(白色念珠菌黑曲霉)的真菌活性以及获得的数据表明,金属配合物比亲本配体更有效地对抗细菌物种。

更新日期:2021-08-29
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