Background

Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression.

Material and methods

We included patients with moderate/severe IEI aged 0–21 years old: cross-sectional study (June2020) to determine the prevalence of COVID-19; prospective study (January2020-January2021) including IEI patients with COVID-19. Assays used: nasopharyngeal swab SARS-CoV-2 PCR and SARS-CoV-2-specific immunoglobulins.

Results

Seven from sixty-five patients tested positive (prevalence: 10.7% (7%–13%)) after the first SARS-COV-2 wave and 13/15 patients diagnosed with COVID-19 had an asymptomatic/mild course.

Conclusions

In our area, prevalence of COVID-19 in moderate/severe IEI paediatric patients after the first wave was slightly higher than in the general population. The majority of patients presented a benign course, suggesting a possible protective factor related with age despite IEI.

中文翻译：

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疫苗前时代高负担地区患有中度/重度先天性免疫缺陷的儿童和年轻人的 COVID-19

背景

关于先天性免疫错误 (IEI) 作为严重 COVID-19 的危险因素的信息很少。我们的目的是确定患有中度/重度 IEI 的儿科患者感染 COVID-19 的水平是否与普通人群相同，并描述 COVID-19 的表达。

材料与方法

我们纳入了 0-21 岁的中度/重度 IEI 患者：横断面研究（2020 年 6 月）以确定 COVID-19 的患病率；前瞻性研究（2020 年 1 月至 2021 年 1 月），包括 IEI COVID-19 患者。使用的检测方法：鼻咽拭子 SARS-CoV-2 PCR 和 SARS-CoV-2 特异性免疫球蛋白。

结果

在第一次 SARS-COV-2 浪潮之后，65 名患者中有 7 名检测呈阳性（患病率：10.7%（7%–13%）），13/15 名诊断为 COVID-19 的患者出现无症状/轻度病程。

结论

在我们地区，第一波之后中度/重度 IEI 儿科患者的 COVID-19 患病率略高于普通人群。大多数患者呈现良性病程，表明尽管 IEI 可能与年龄相关的保护因素。